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2017 Berea College Research Symposium

The 17th annual Berea Undergraduate Research Symposium (BURS), held this fall the same weekend as the Berea College Trustees (of which Rocky Tuan is a member) visit campus. This has been organized by the science programs in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The program for Fall 2017 will be held on Friday, October 20th. The 2017 BURS will start in the afternoon with student oral presentations, continue with student poster presentations, and end with a plenary talk by Dr. Rocky Tuan, Berea College Alumnus and Professor at the University of Pittsburgh.

Application of 3D Microtissue Chip Technology to Study Composite Skeletal Tissue Physiology: Microgravity-Induced Pathologies and Drug Screening

Abstract - Skeletal disorders, including osteoporosis and osteoarthritis, present a significant disease burden for the general population, and are specifically associated with space flight, such as accelerated bone loss. We have recently developed a 3D microphysiological system (MPS), utilizing adult stem cells, biomimetic materials, and 3D printing technologies, that mimics osteochondral tissues. The microfluidically perfused MPS bioreactor can accommodate both stem cell-engineered tissues and primary osteochondral tissues, and is amenable to high-throughput screening and testing of potential therapeutics for bone and cartilage health. The MPS is particularly suitable as an on-board experimental model to study the accelerated skeletal pathologies observed during space flight, as well as a high utility system applicable for predictive toxicology and drug development for skeletal tissues, both on the ground and in space.
We will start at 2:30 PM with two simultaneous oral presentation sessions (15 minutes each) in rooms 101 and 106 of the Science Building. The sessions are grouped by theme as much as possible. The poster session starts at 3:00 and is held in the lobby of the science building with posters from various fields (previous posters from chemistry, biology, physics, psychology, sociology, education, African American Studies, economics, industrial arts, computer science, physical education & health, and mathematics). All students who pursued substantial research projects over the previous year are encouraged to present their research.
We have been hosting the BURS since 2001 and have records of participants going back to 2007 online (see links to the left).
Students and faculty interested in attending or participating in the 2018 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

Synthesis of Cleavable Acetal Antibody Drug Conjugate

Isaac Mendoza, Luis Guzman Salazar
Mentor: Elizabeth Thomas
Performed at Berea College
The design of a hydrophilic heterobifunctional linker with the functionality to conjugate to a monoclonal antibody, mAb, was our research goal. When drug toxins are bound to the linker that is conjugated to a mAb, these molecules are known as antibody-drug conjugates, ADC’s. Linking drug toxins to mAbs is a way to deliver drug molecules specifically to cancer cells without targeting the healthy cells within the body. This minimizes the toxic effects of chemotherapy treatments. A heterobifunctional linker is functionalized on two separate ends of the small organic molecule. One end of the linker facilitates covalent bonding to the mAb while the other end facilitates covalent bonding to a toxin drug molecule. The mAbs that we are interested in bind specifically to the extracellular matrix (outside cell surface) of cancer cells; in particular antibody CD-55. Our desired linker consisted of a uridine molecule covalently bonded to maleimide through an acetal moiety. The importance of the acetal is that this functional group is cleavable at a pH of 5.5 and therefore, once endocytosed (brought inside the cell membrane) within the cancer cell, should cleave to release the drug toxin. Outside the cell membrane is a pH of 7.2. Acetal functions are stable at pH of 7.2 and therefore would remain intact outside the cancer cell. The simulated cancer drug is uridine, however, 5-fluorouridine is a known cytotoxin that can be attached to the heterobifunctional linker in place of uridine once the chemistry has been established. We successfully synthesized the final intermediate precursor to the desired product containing the uridine group. Ideally, once the final product is synthesized, further research would be conducted to demonstrate the cleavage efficiency of the desired compound and then the synthesis of the 5-fluorouridine ADC for evaluation as a cytotoxin specific towards cancer cells that express CD-55.

Registration for the 103rd Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2017

Oral Presentations

# Name Title Major
1 Chi Peng Biology of the Cercaria of Leuceruthrus micropteri (Trematoda: Azygiidae) Recovered from the Snail, Pleurocera semicarin abstract biology
2 Jazmin Escamilla Hepatitis C virus entry inhibitor Aryloxazole modulates Autophagy abstract biology
3 Hannah Elliot, Muntathar Alshimary, Rebecca Klem, Jeremy Wilde Factors Affecting the Diversity of Stream Salamanders in Two Watershed Systems in Central Kentucky abstract biology
4 Emma Reasoner Pinniped Husbandry, Training, and Conservation at the Indianapolis Zoo abstract biology
5 Claire Thelen Immunoglobulin Y Levels in Spectacled and Steller’s Eider Sea Ducks As Indicators of Disease and Population Decline abstract biology
6 Hannah Carter Influence of reclaimed surface mine landscape on bees and plant-pollinator networks in southeastern Kentucky abstract biology
7 Sunaina Sherchan Antioxidant Treatment for Closed Globe Ocular Blast Trauma abstract biology
8 Seth Reasoner Characterization of Host-Pathogen Interactions during Early Stage Chikungunya Virus Infection abstract chemistry
9 Issac Domenech Identification of Selective DDR1 Kinase Inhibitors Using Structure Activity Relationship abstract chemistry
11 Emma Batson, Gracie Casciola Appalachian Nature Education Study abstract child and family studies
12 Logan Paisley A Summer at Summit: Applied skills in the world of Civil Engineering abstract other
13 Annie He, Samantha Sise, Alicia Crocker, and Bianca Godden A Study of George White through Flight and Light abstract other
14 Bhavesh Ramkorun Imaging of the Spinal Cord in Pediatric Patients abstract physics
15 Talha Rehman Designing Computer Based Interface Between X-Ray Generator, and Stages For Coded Aperture Coherent Scatter Spectral Imaging (CACSSI) abstract physics
16 Khawla Nasser Al Deen Mashrou3 Insan (the Human Project): A Participatory Action Research Project on Displaced Youth's Mental Health and Well-Being abstract psychology

Poster Presentations

# Name Title Major
1 Favour Akabogu Triops Cancriformis: A Potential Non-mammalian Animal Model for Studying the Mechanisms of Kidney Ultrafiltration. abstract biology
2 Amber Follin Identifying genetic modifiers in a Drosophila model of Inclusion Body Myopathy abstract biology
4 Marah Zeidan Improving Long Term Outcomes in Retinoblastoma survivors. abstract biology
5 Allison Harper Measurement of Influenza Severity in Tennessee Hospitalized Patients, 2016-2017 abstract biology
6 Matalynn Shealy A Gastroparesis Study on the Reinstitution of Oral Nutrition from J-tube Placements abstract biology
7 Sydney Short Hybrid ECMO Using Double Lumen Cannula Ensures Adequate Heart/Brain Oxygen Supply abstract biology
8 Sara Garner, Tomas Flores, Shay Steele Measurement of Chemical Shift Tensors and J-Coupling in Sodium/Lead Mixed Pyrophosphate Glasses abstract chemistry
9 Sarah Tabor, Michael James Synthesizing Cleavable Acetal Antibody Drug Conjugates abstract chemistry
10 Isaac Mendoza, Luis Guzman Salazar Synthesis of Cleavable Acetal Antibody Drug Conjugate abstract chemistry
11 Kateryna Nabukhotna Integrin β-1 Promotes KRAS-Mutated Lung Cancer Viability via FAK Activation abstract chemistry
12 Clara Reasoner GC-MS Analysis of Volatile Organic Compounds in Metastatic and Non-Metastatic Breast Cancer Cells abstract chemistry
13 Luis Gonzalez Anguiar Selective C–O bond reductions in carbohydrate derivatives using boron based reagents abstract chemistry
14 Amber Earlywine Targeting Proteolytic Activity Using Protease Inhibitors as Natural Therapeutics for Human Metapneumovirus (HMPV) abstract chemistry
15 Mario Chavarria, Cheyenne Haynes N-Heterocyclic Carbene Complexes abstract chemistry
16 Beau Schweitzer Synthesis of Poly(4-hydroxystyrene) by Living Anionic Polymerization for Block Copolymer Lithography abstract chemistry
17 Aubree Zimmer Determination of actinomycin Y1 aryl amine reactivity in the production of Y5 abstract chemistry
18 Dusty Cole, Vincent Davis, Michael Moorer DESIGN AND IMPLEMENTATION OF A WEB-BASED SIMULATION abstract computer science
19 Lakshiya Indreswaran Optimal Strategy for Partisan Combinatorial Games: The case of a Little Bit of Aggression abstract computer science
20 Miguel Valdes The POGIL Approach Used in NonStem Disciplines abstract education
21 Sara Ullom, Cherokee Griffiths, Rebecca O'Connor Analyzing Trade Books and Other Print Media for Classroom Use abstract education
22 Alexandra Yuhas, Aric Parker, Gyanu Karki, Samriddha KC Combinatorial Game Theory: A Game of Aggression abstract mathematics
23 Anna Joines Marginal fracture of amalgam restorations and amalgam’s resistance to low frequency biaxial fatigue abstract other
24 Lauren S. Heller Advancing a stem cell-based therapy for epidermolysis bullosa simplex through the utilization of the CRISPR/Cas9 system to knockout the mutant K14 gene abstract other
25 Daniela Olivera Velarde Data analysis of JPARC run to test Current-Mode Detector for Use in NOPTREX Time Reversal Experiment abstract physics
26 Dustin Watts Distinguishing Important Differences between the Sample Forms of LiGaCr4O8 abstract physics
27 Kemo Jammeh, Mo Thi Variable Star Astronomy: Observing The Pattern of Change in Select Variable Stars abstract physics
28 Dzhoana Ivanova Modeling the mid Infrared emission from NGC 595 abstract physics
29 Alicia Bedolla, Evelyne Rivera, Joey Barger, Jasmine Roman Betta fish (Betta splendens) spontaneously use the combination of numerosity and surface area during discrimination learning abstract psychology
30 Jennifer Bentz, Jessica Cox, Bethany Howard, and Aldrin Vinton Psychology and Social Class: Examining Our History, Beliefs, and Outcomes abstract psychology
31 Constantine Botimer, Chance Davis, Jedidiah Radosevich, Chris True Biomass Stove Design Project: Automated Fuel Feeder System abstract technology & industrial arts