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Science Building
CPO 2191
859-985-3318

Office Hours:
M–F, 8:00 a.m.–5:00 p.m.

Contact:
jay_baltisberger@berea.edu

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2015 plenary speaker, Professor Roy Zent

2015 Berea College Research Symposium

The Berea Undergraduate Research Symposium (BURS), held this fall the weekend after the Berea College Trustees visit campus. This has been organized by the science programs in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The program for Fall 2015 will be held on Friday, October 23rd. The 2015 BURS will start in the afternoon with student oral presentations, continue with student poster presentations, and end with a plenary talk by Roy Zent, MD, PhD from Vanderbilt University School of Medicine. Professor Zent works in the Nephrology and Hypertension Division of the School of Medicine and his research works on the basic role of integrins in epithelial cell biology. He also collaborates with Dr. Charles Sanders performing structural functions on integrins using NMR spectroscopy.
We will start at 2:30 PM with two simultaneous oral presentation sessions (15 minutes each) in rooms 101 and 106 of the Science Building. The sessions are grouped by theme as much as possible. The poster session starts at 3:30 and is held in the lobby of the science building with posters from various fields (previous posters from chemistry, biology, physics, psychology, sociology, education, African American Studies, economics, industrial arts, computer science, physical education & health, and mathematics). All students who pursued substantial research projects over the previous year are encouraged to present their research.
We have been hosting the BURS since 2001 and have records of participants going back to 2007 online (see links to the left).
Printable program for 2015 symposium
Students and faculty interested in attending or participating in the 2018 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

TRIM24 Induces Epithelial to Mesenchymal Transition (EMT) in MCF10A Cells

Bruce Plowshay Jr.
Mentor: Dr. Michelle Barton, Ph.D
Performed at The University of Texas MD Anderson Cancer Center
TRIM24 is a newly discovered protein of interest due to its role in tumorigenesis of breast and liver cancer. Our research was conducted using normal immortalized MCF10A cells to determine if TRIM24-overexpression induced a mesenchymal phenotype and the potential glucose metabolism genes that were allowing an Epithelial to Mesenchymal Transition (EMT) -like process. We overexpressed TRIM24 using lentiviral infection, mutated the PHD and Bromodomains of TRIM24 to determine which protein domain might have played a role in EMT, utilized qPCR to amplify designated glucose metabolism and cell adhesion genes, and finally utilized a Boyden chamber assembly assay to measure the amount of migration. Our experiments, most importantly, showed a change in morphology of MCF10A cells upon over expressing TRIM24, and a nearly 100% migration upon imaging the Boyden chambers containing the MCF10A cells. Main conclusions of these experiments are that TRIM24 interacts with membrane proteins e-cadherin, vimentin, and n-cadherin; TRIM24 induces a mesenchymal phenotype upon overexpression; and TRIM24 overexpression resulted in a large magnitude of migration. Further studies include an invasion-type assay, and quantitative analysis of a more diverse class of EMT and glucose metabolism genes.


Registration for the 103rd Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2015

Oral Presentations

# Name Host Title Mentor Major
1 Kaitlyn Reasoner Vanderbilt University pH induced compaction of the N-terminal domain of lipidated caveolin-3. abstract Dr. Charles Sanders biology
2 Kevin Montgomery, Moondil Jahan, Olamide Adejumo Berea College Physiological Dormancy and Germination Patterns in Seeds of the Rare Yellow Gentian (Gentiana flavida Muhl.) abstract Christopher A. Adams biology
3 Olamide Adejumo, Moondil Jahan, and Kevin Montgomery Berea College Dormancy-Breaking and Germination Patterns in Seeds of Calycanthus floridus L. (eastern sweetshrub) abstract Christopher A. Adams biology
4 Moondil Jahan, Kevin Montgomery, and Olamide Adejumo Berea College Comparison of Dormancy States and Germination Patterns in Seeds of Calycanthus floridus L. (eastern sweetshrub) abstract Christopher A. Adams biology
5 Gabrielle Christian Berea College; Grow Appalachia Evaluating the Impact of Community Gardens in the Appalachia Region abstract Dr. Lisa Turner biology
6 Hsuan Peng University of Pittsburgh The Bioactivity of Pericellular Matrix from Adult Stem Cells abstract YANGZI JIANG, ROCKY S. TUAN biology
7 Chi Peng Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado Denver The Dynamics of Immunoediting in Skin Carcinogenesis abstract Dennis Roop biology
8 Zachary Spicer, Jeremy Wilde, Morgan Stacy Berea College Diversity of Stream Salamanders in Relation to Human Disturbance and Watershed Affiliation in Central Kentucky. abstract Roy Scudder-Davis biology
9 Kyaw Hpone Myint The Ohio State University Dissipative Particle Dynamics (DPD) Simulations of Hard Nanoparticle-encapsulated Polymeric Micelle Formation abstract Dr. Barbara Wyslouzil chemistry
10 Seth Reasoner Vanderbilt University Medical Center Type 1 Interferon Expression Following Small Molecule Inhibition of Cyclic GMP-AMP Synthase abstract Manuel Ascano chemistry
11 Dorothy Coe & Katie Bragdon Berea College A Simple Mechanochemical Aryl Bromination Procedure abstract Nicholas Marshall chemistry
12 Jonah Rector Pepperdine University The Effects of Heat Shock Preconditioning on Protein Induction and Cell Survival after Nanoparticle Exposure abstract Dr. Jay Brewster chemistry
13 Tatiana Mikhailova Vanderbilt University IDENTIFICATION OF FACTORS STABILIZING THE 3D STRUCTURE OF THE GOODPASTURE AUTOANTIGEN OF GLOMERULAR BASEMENT MEMBRANE abstract Dr. Vadim Pedchenko, Dr. Billy Hudson chemistry
14 Lydia Bauler, M. Ethan Johnson, and Joseph Carrick Berea College & Chicago, IL Understanding Maps as Argument: Decoding Spacial Constructs abstract Jason Cohen other

Poster Presentations

# Name Host Title Mentor Major
1 Lillian Setters, Amanda Burns Berea College Soil Quality at Berea College Farm abstract Dr. Mary Parr agriculture and natural resource
2 Jane Hostomsky Berea College Effects of protein supplementation on the parasite susceptibility and growth performance of lactating does and continuously suckled kids raised in a sustainable production system at Berea College Farm abstract Dr. Quinn Baptiste agriculture and natural resource
3 Maria Anastasiadou University of Colorado Denver Engineering stress-resistant mouse Embryonic Stem (ES) cells abstract Wallace Chick biology
4 Meghan Kramer Chicago Botanic Garden Broadening definitions of plant biodiversity in restored tallgrass prairies abstract Evelyn Williams, Rebecca Barak, Dan Larkin biology
5 Geri Mitchell, Jessica Vinson, Sean Nilan Berea College Comparisons between Prey Species in Barn Owl (Tyto alba) Pellets Collected in 1988, 1996, and 1997 from a Silo Roost in Harrogate, Tennessee abstract G. Neil Douglas biology
6 Jazmin Escamilla Vanderbilt Medical Center Division of Nephrology Lysyl Oxidase Homolog Extracellular Processing abstract Roberto Vanacore, Alberto J. López-Jiménez biology
7 Sophia Toe Vanderbilt University Medical Center Integrin subunits α3 and α6 mediate FGF10-dependent signaling events in collecting duct cells bound to LM511 abstract Eugenia Yazlovitskaya, Roy Zent biology
8 Sarah W. Tabor, Sam C. Moody Berea College Does membrane composition affect whole-animal performance and thermal tolerance in the eastern newt (Notophthalmus viridescens)? abstract Patrick M. Mineo biology
9 Sunaina Sherchan, Sarah Tabor Berea College Thermal tolerance differs between terrestrial and aquatic life history stages in the eastern newt (Notophthalmus viridescens) abstract Dr. Patrick Mineo biology
10 Morgan Stacy, Jeremy Wilde, Zachary Spicer Berea College A Preliminary Species Identification for an Isolated Population of Salamanders of the Plethodon glutinosus complex. abstract Roy Scudder-Davis biology
11 Hanna Abe Vanderbilt University Identification of Lead Compounds That Differentially Target Integrin α1β1 and α2β1 I-Domains for The Treatment of Kidney Fibrosis abstract Billy Hudson & Kyle Brown biology
12 Kodey Blankenship Berea College Solid-state NMR Study of Crystalline Pyrophosphate Salts abstract Jay Baltisberger chemistry
13 Boubacar Cherif The Ohio State University CHEMICAL AND PHYSICAL RESISTANCE OF GUAYULE AND NITRILE BLEND RUBBER GLOVES abstract Katrina Cornish chemistry
14 Kidist Ashami Vanderbilt University Expression and Purification of Transforming Growth Factor Receptor β-ii Cytoplasmic Tail from Ecoli. abstract Ambra Pozzi chemistry
15 Alaina Fox Louisiana Tech University Effect of FeRu Core-shell Catalysts Size on Fischer–Tropsch Reactions abstract Dr. Daniela Mainardi chemistry
16 Tyler Hutsell, Marco Santos Berea College Mechanochemical chlorination and iodination of electron-rich aromatics abstract Nicholas Marshall chemistry
17 Bruce Plowshay Jr. The University of Texas MD Anderson Cancer Center TRIM24 Induces Epithelial to Mesenchymal Transition (EMT) in MCF10A Cells abstract Dr. Michelle Barton, Ph.D chemistry
18 Samuel A. Effoe, Benjamin R. Quesada, Maria S. Ledesma-Alonso, Lyndsey J. Barker Berea College New Methods to Synthesize Nickel N-Heterocyclic Carbene Complexes abstract Anes Kovacevic chemistry
19 Lyndsey J. Barker, Maria S. Ledesma-Alonso, Samuel A. Effoe, Benjamin R. Quesada Berea College Abnormal N-Heterocyclic Carbene Complexes abstract Dr. Anes Kovacevic chemistry
20 Tatiana Mikhailova, Brennan Taylor Berea College Rapid, electroless surface modification through surface-directed azo coupling abstract Dr. Nicholas Marshall chemistry
21 John Attelah, Gracia El Ayle Georgetown University Synthesis of Amine-Functionalized Cyclotribenzylenes (CTBs) abstract K. Travis Holman chemistry
22 Job Limo University of Nairobi, Kenya Phytochemical Investigation of Albizia Shimperiana and Bridelia Micrantha for Cytotoxic Principles Against Drug Sensitive and Multidrug Resistant Cancer Cell Lines abstract Leonidah Kerubo chemistry
23 Andrew Norris, Sean Harvey, Andreas Riegger University of Ulm, Ulm, Germany Functionalization Work on Dopamine Nanoparticles with the Incorporation of Human Serum Albumin (HSA) and Unnatural Amino Acid Synthesis abstract Tanja Weil & David Yuen Wah Ng chemistry
24 Ebony Adams Google IT Support within the Corporate Environment Today Scott Heegan computer science
25 Carlos, Andres, Berejnoi, Bejarano Berea College Developing an Affordable Traffic Counting System Using Computer Vision abstract Matt Jadud computer science
26 Bria Williams, Kristian Toole Berea College Computer Science Program Design and Development of a Bio-Inspired Robotic Quadruped Using Programmable Central Pattern Generators abstract Prof. Scott Heggen; Prof. Matthew Jadud computer science
27 Amber Tolleson, Ashley Aiken Berea College The Detection of Gas in Fracking Contaminated Water abstract Matt Jadud computer science
28 Noah Broomfield, Lindsey Harper, Felicia Flesch Berea College A Student Built Wood Kiln: Exploring Sustainable Practices in the Ceramics Studio abstract Philip Wiggs other
29 Madelaine Collett, David Battoe Berea College Lawn Care abstract Daniel Feinberg other
30 Joseph Carrick Berea College Network Analysis in Colonial State Papers abstract Jason Cohen other
31 David Orr, Colin Weckman Berea College A comparison of optical versus electrical heart rate monitoring across various exercise intensities and modalities. AJ Mortara Ed.D. CSCS physical education & health
32 Dadbeh Shaddel UK Image reduction for MaAGA Renbin Yan physics
33 Nicholas Hubbard United States Air Force Research Laboratory Millimeter Wave Propagation Through the Atmosphere Dr. Steven Lane physics
34 Denzell Barnett Kennesaw State University Differential Thermal Analysis of Bioactive Glass Material for Bone Tissue Regeneration abstract Tracy Hodge physics