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Science Building
CPO 2191

Office Hours:
M–F, 8:00 a.m.–5:00 p.m.


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2014 plenary speaker, Professor Kathryn Uhrich

2014 Berea College Research Symposium

The Berea Undergraduate Research Symposium (BURS), held each fall the same weekend that the Berea College Trustees visit campus, is an opportunity for the students and faculty to share research work with each other as well as these important campus visitors. This has been organized by the science programs in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The program for Fall 2014 will be held on Friday, October 17th. The 2014 BURS will start in the afternoon with student oral presentations, continue with student poster presentations, and end with a plenary talk by Kathryn Uhrich, Professor of Chemistry at Rutgers University where she has served as Associate Chair as well as Dean of Mathematical and Physical Sciences. She will be speaking about her research on biologically active polymer drugs and related topics. She will be arriving in Berea before the symposium and anyone interested in talking to her about graduate school or her research in general should contact Jay Baltisberger.
We generally start at 2:30 PM with two simultaneous oral presentation sessions (15 minutes each) in rooms 101 and 106 of the Science Building. The sessions are grouped by theme as much as possible. The poster session starts at 3:30 and is held in the lobby of the science building with posters from various fields (previous posters from chemistry, biology, physics, psychology, sociology, education, African American Studies, economics, industrial arts, computer science, physical education & health, and mathematics). All students who pursued substantial research projects over the previous year are encouraged to present their research.
We have been hosting the BURS since 2001 and have records of participants going back to 2007 online (see links to the left).
Printable program for 2014 symposium
Students and faculty interested in attending or participating in the 2017 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

Role of IFNγ in Experimental Autoimmune Encephalomyelitis

Aylssa Hubbard
Mentor: Chella David
Performed at Mayo Graduate School
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) of presumed autoimmune origin. Of all the genetic factors linked with MS, MHC class-II molecules have the strongest association. Generation of HLA class-II transgenic (Tg) mice has helped to elucidate the role of HLA class-II genes in MS. Utilizing HLA class-II Tg, it has been shown that IFNγ may actually have a protective role in MS and experimental autoimmune encephalomyelitis (EAE). To further confirm the role of IFNγ in protection, we generated DRB1*0301.DQ8 mice lacking IFNγ (DRB1*0301.DQ8. IFNγ -/-). Immunization of FNγ deficient mice with PLP91-110 peptide led to development of atypical EAE characterized by ataxia, head tilting, and gait problems. IFNγ deficient mice with atypical EAE showed severe inflammation and demyelination in the brain with no/mild spinal cord pathology. In contrast, IFNγ sufficient mice develop classical paralytic EAE with spinal cord pathology. This study attempted to determine why IFNγ deficient mice developed atypical EAE with brain pathology. Therefore, in this study we compared chemokine/cytokine profiles and the cellular profile in the brain between the IFNγ deficient and sufficient mice. Previously, monocytes and IL-17 have been shown to play an important role in the disease pathogenesis, therefore, we depleted monocytes using liposomes and neutralized IL-17 using Anti-IL17 antibody to investigate their effect on pathogenesis. Chemokine and cytokine expression were analyzed by RT qPCR of brain RNA from both IFNγ sufficient and deficient mice. The presence of different cells types in the mice were determined by immunofluorescence. We observed that IFNγ deficient mice had an increased expression of the Th17 cytokine/chemokine profile and had increased levels of microglia in regions with pathology. Depletion/neutralization studies indicate that monocytes and IL-17 are important for pathology, as both suppressed development of EAE.

Registration for the 103rd Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2014

Oral Presentations

# Name Title Major
1 Hsuan Peng Investigating the multipotency potential of chondrogenic progenitor cells abstract biology
2 Lin Peng Understanding the Role of Myc In Squamous Cell Carcinoma abstract biology
3 Ray Isinga Mirembo Proximal NPxY motif of integrin beta1 is important for the regulation of growth factor dependent cell signaling abstract biology
4 Michon Martin, Taylor Fagin, Brenna Goldberg, Sean Nilan, Leif Van Laar Isolation, Disturbance, and Watershed Affiliation as Factors in the Diversity and Abundance of Stream Salamanders in Central Kentucky abstract biology
5 Amber Crabtree Effect of Glucose on LOX Expression in Renal Cells biology
6 Amanda Burns*, Helen L. Holmlund and Victoria M. Lekson Seedling survival after novel drought-induced germination in Ceanothus megacarpus abstract biology
7 Moondil Jahan, Rhea P. Sharma, G. Neil Douglas, Ralph L. Thompson Comparison of Barn Owl (Tylo alba L.) Prey from a Silo Roost in Claiborne Co., TN. abstract biology
8 Chi Peng SCN Prevents HOBr-mediated Formation of Sulfilimine Crosslinks in Collagen IV Scaffolds abstract biology
9 Lauren Ballou*, Hanna Abe, Kidist Ashami, Olamide Adejumo, Kevin Montgomery and Sophia Toe Prevalence and Mean Intensity of Cotylaspis insignis (Trematoda: Aspidogastridae) Infections in the Fat Mucket, Lampsilas siliquoidea (Bivalvia: Unionidae) at North Elkhorn Creek, and Location of its Egg Development. abstract biology
10 Caleb M. Krebs, Jacob P. McClain, and Jonathon D. Terrell Dormancy-Breaking and Germination Requirements for Seeds of the Kentucky Endangered Yellow Gentian Gentiana flavida A. Gray (Gentianaceae). abstract biology
11 Michael McCann Photocatalyzed Benzylic Fluorination: An Alternative Approach through Radical Cations abstract chemistry
12 Michael Oxendine Leaded paint as a source of soil lead in Berea, Kentucky abstract chemistry
13 Mikiyas Kurabachew Assefa Infrared Photodissociation Spectroscopy of Metal Carbonyls abstract chemistry
14 Pyae Phyo Simulations of magic-angle flipping experiments on alkali and alkaline earth silicate glasses abstract chemistry
15 Yunpeng Xia*, Chioma Amaechi, Willie Gosnell, Judith Weckman, Sarah Blank Helping Students Succeed in Anatomy and Physiology II: A Study of a Peer Assisted Learning Program abstract other
16 Chioma Amaechi*, Willie Gosnell, Yunpeng Xia, Judith Weckman, Sarah Blank Helping Students Succeed in Anatomy and Physiology I: A Study of a Peer Assisted Learning Program abstract other
17 Haley Boothe Spreading Knowledge of a Recent Gift to a Larger Community abstract other

Poster Presentations

# Name Title Major
1 Sydney Marshall, Cydney Hill The growth performance and parasite susceptibility of goat kids and postpartum performance of does managed in continuous suckling systems at sustainable production operations of Berea College and Community Producer Farms agriculture and natural resource
2 Kaitlyn Reasoner A novel and interactive method for teaching DNA replication. abstract biology
3 Michon Martin, Taylor Fagin, Brenna Goldberg, Sean Nilan, Leif Van Laar Water Level and Feeding Regimen as Factors Promoting Metamorphosis in Laboratory-Reared Southern Two-Lined Salamanders, Eurycea cirrigera. abstract biology
4 Jenna Rufer Towards inhibition of tumor angiogenesis through disruption of collagen IV scaffold assembly by anti-NC1 antibodies abstract biology
5 Lauren Ballou*, Hanna Abe, Kidist Ashami, Olamide Adejumo, Kevin Montgomery and Sophia Toe Prevalence and Mean Intensity of Cotylaspis insignis (Trematoda: Aspidogastridae) Infections in the Fat Mucket, Lampsilas siliquoidea (Bivalvia: Unionidae) at North Elkhorn Creek, and Location of its Egg Development. abstract biology
6 Bailey Wiggins, Maria Anastasiadou Isolation and characterization of plasmids from normal flora E. coli abstract biology
7 Sheniqua Austin Counteracting antibiotic resistance in Pseudomonas through antibiotic combination abstract biology
8 Jordan Butts Potential benefit of the T-cell migration inhibitor FTY720 in Toxic Shock Syndrome biology
9 Lin Peng*, Kaitlyn Reasoner* and Ericka Berg In Vitro Egg Development in the Trematode, Cotylaspis insignis (Subclass Aspidogastrea). abstract biology
10 Hanna Abe*, Kidist Ashami*, Lauren Ballou, Olamide Adejumo, Kevin Montgomery and Sophia Toe Cotylaspis insignis (Trematoda: Aspidogastridae): Effect of Osmolality on Adult Worm Survival, Egg Production and Rate of Development. abstract biology
11 Olamide Adejumo*, Kevin Montgomery*, Sophia Toe*, Hanna Abe, Kidist Ashami and Lauren Ballou Proterometra macrostoma (Trematoda: Azygiidae): Effect of Serotonin on Redial Movement and Emergence of Cercariae from Rediae and Snails, Elimia semicarinata (Gastropoda: Pleuroceridae). abstract biology
12 Seth Reasoner Synthesis, Purification, and Structural Characterization of Organic Processing Impurities abstract chemistry
13 Anthony Boateng Synthesis of Fluorinated Homoallylic Compounds via Ring-Opening Nucleophilic Fluorination of Methylene Cyclopropanes (MCP) abstract chemistry
14 Andrew Norris The Solid-Phase Organic Synthesis of a Fluorescence-Quenching Analog of Lysine abstract chemistry
15 De’Angela Brooks-Townsend, Tyller Culver, Jonah Rector Synthesis of Fluorogenic Peptide Substrates for the Peptidase Neurolysin. abstract chemistry
16 Kyaw Hpone Myint*, Solomon Tesfamichael, Pyae Phyo, Brennan Walder Combining an extended Czjzek model with spinning sideband simulations of magic-angle turning (MAT) experiments on phosphate glasses abstract chemistry
17 Solomon Tesfamichael, Kyaw Hpone Myint Phase-incremented Echo Train Acquisition (PIETA) experiments to measure J-coupling in new phosphate glasses abstract chemistry
18 Kathryn Dunn, Moondil Jahan, Justin Dean Burton, Sean Riley, Robert Horn II Establishing the Past Lives of Appalachia in the Berea College Forest abstract other
19 Willie Gosnell*, Chioma Amaechi, Yunpeng Xia, Kristen Lynch, Sarah Blank Creation of interactive manipulatives and educational games, and determination of their effectiveness in improving students’ understanding of Anatomy and Physiology abstract other
20 Barbara Hollstein Gathering the Stories of Appalachian Foodways: An Oral History Research Project other
21 Laura Abelquist Boron Nitride Nanotube Composite Aerogels other
22 Cassie Bodenste, Tyler Huff A Comparison of the Metabolic Costs of Elliptical Training Versus Treadmill Running physical education & health
23 Brandon Schurter How Hub Cells Hijack Neuronal Networks abstract physics
24 Aylssa Hubbard Role of IFNγ in Experimental Autoimmune Encephalomyelitis abstract psychology
25 Sydney Henderson, Tiffany Estep Healthy, Hunger-Free Kids?: Results from an Elementary School Lunch Program Evaluation abstract sociology