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2011 Berea College Research Symposium

The Berea Undergraduate Research Symposium (BURS), held each fall the same weekend that the Berea College Trustees visit campus, is an opportunity for the students and faculty to share research work with each other as well as these important campus visitors. This has been organized by the science departments in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The program for Fall 2011 will be held on Friday, October 21st. The 2011 BURS will start in the afternoon with student oral presentations, continue with student poster presentations, and and with a plenary talk by Dr. Doug Stickle. Dr. Stickle is Professor and Director of Chemistry & Point-of-Care Testing (POCT) at Jefferson University Hospitals in Philadelphia. Dr. Stickle's talk is titled, “Clinical Chemistry, and Clinical Applications of Mass Spectrometry”.
We will start at 2:30 PM with two simultaneous oral presentation sessions (15 minutes each) in rooms 101 and 106 of the Science Building. The sessions are grouped by theme as much as possible. The poster session starts at 3:30 and is held in the lobby of the science building with posters from various fields (previous posters from chemistry, biology, physics, psychology, sociology, education, African American Studies, economics, industrial arts, computer science, physical education & health, and mathematics). All students who pursued substantial research projects over the previous year are encouraged to present their research.
Students and faculty interested in attending or participating in the 2018 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

The mechanism of action of Prevotella histocola in the immunomodulation of experimental autoimmune encephalomyelitis (EAE).

Premila Samuel
Mentor: Ashutosh Mangalam
Performed at Mayo Clinic
Multiple sclerosis (MS) is an inflammatory autoimmune disease affecting the central nervous system. Genetic and environmental factors may interact in different ways to influence the outcome of MS. Recently, a lot of interest has been generated in studying the role of gut microbiota as a possible environmental factor in the immunopathogenesis of MS. This hypothesis is supported by recent reports that patients with inflammatory diseases have reduced fecal levels of certain commensal bacteria, suggesting possible immunomodulatory role of commensal bacteria in these diseases. Previously, we have shown that human gut specific commensal bacteria, Prevotella histocola can suppress experimental autoimmune encephalomyelitis (EAE), an animal model of MS, in HLA-DR3.DQ8 transgenic mice. In this study, we investigated the mechanism of action of immunomodulatory activity of P. histicola by investigating the ability of P. histicola to modulate pro and anti-inflammatory cytokine production in lipopolysaccharides (LPS) stimulated epithelial and dendritic cells. Our preliminary data show that the in vitro treatment of Caco-2, a human intestinal epithelial cell line, and THP-1, a human monocytic cell line, with P.histocola supernatant resulted in the down-regulation of pro-inflammatory cytokines TNF-α and IL-8 and the up-regulation of anti-inflammatory cytokine IL-10. Likewise, the in vitro treatment of dendritic cells and macrophages (derived from HLA-DR3.DQ8 double transgenic mice) with P. histocola supernatant suppressed the production of TNF-α, while inducing the production of IL-10. Thus our preliminary data indicate that P. histocola might suppress EAE in HLA class II transgenic mice through modulation of pro and anti-inflammatory cytokines.

Registration for the 103rd Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2011

Oral Presentations

# Name Title Major
1 Ericka Berge, Bailey King, Michon Martin, Juliana Dolan, & Franceska Mehmeti Proterometra macrostoma (Trematoda: Azygiidae): Location of the Redia and Emergence Path from the Snail Intermediate Host, Elimia semicarinata (Gastropoda: Pleuorceridae). abstract biology
2 Imelda Hot Blood Plasma Coagulation Induced by Poly(ethylene glycol) Materials abstract chemistry
3 Marceline G. Aengwanama Runx1 Interacts with Delta Np63alpha to Regulate Target Genes abstract chemistry
4 Kelly Mouapi Epitope Mapping of Vimentin in Arthritis-susceptible HLA-DRB1* 0401 and resistant *0402 mice abstract chemistry
5 Premila Samuel The mechanism of action of Prevotella histocola in the immunomodulation of experimental autoimmune encephalomyelitis (EAE). abstract chemistry
6 Chido Hambira & Michael Bertucci Combinatorial synthesis of a thiourea library for the aminolysis of N-acyl homoserine lactones abstract chemistry
7 Lydia Joiner Berea College Gardeing Project abstract child and family studies
8 Tommy O. Boykin Synthesis of Copper-Based Superconductors abstract physics
9 Rohan Isaac, Tommy Boykin, Marissa Brown, & Mackenzie Endres Synthesis and characterization of Half-Metallic Heusler Alloys abstract physics
10 Rachel Krebs The effects of gender and writing assignments on implicit attitudes of gender roles abstract psychology
11 Raven Weaver Perception of Aging: The Power of Knowledge & Action abstract psychology

Poster Presentations

# Name Title Major
1 Juliana Dolan, Franceska Mehmeti, Ericka Berg, Bailey King, & MIchon Martin Proterometra macrostoma (Trematoda: Azygiidae): Effect of Serotonin and Melatonin on Redial Movement and Emergence of the Cercaria from the Redia and the Snail, Elimia semicarinata (Gastropoda: Pleuorceridae). abstract biology
2 Karen Reynolds Understanding SERF function: Creation and behavioral analysis of dSERF deletion mutants abstract biology
3 Katherine Webb Detection and mapping of invasive plant species and hiking trails at Indian Fort Mountain in Berea, KY. biology
4 Cecilia Albers The Role of Activated Leukocyte Cell Adhesion Molecule in Triple Negative Breast Cancer abstract biology
5 Charli Bobbitt The Role of Bone Morphogentic Proteins in Mammary Gland Differentiation biology
6 Horton Li LKB1 effect on MicroRNA expression in lung adenocarcinoma abstract chemistry
7 Dallas Cook, Russell Hammond, & Horton Lin Synthesis of Fluorescent Derivatives of Lysine and Glutamic Acid abstract chemistry
8 Trena Payton & Amanuel Tefamichael Synthesis of Enantioenriched β-Ketoesters via a Quinine-Catalyzed Ketene-Claisen Condensation. abstract chemistry
9 Chelsey Lloyd & Michelle Bloom Synthesis of Enantioenriched β-Ketoesters via an Azaferrocene-Catalyzed Ketene-Claisen Condensation abstract chemistry
10 Amanuel Tesfamichael & Trena Payton Synthesis of Enantioenriched β-Ketoesters via a Ketene-Claisen Condensation. chemistry
11 Diego Moya, Elijah Whitaker, Melanie Burt, & Julianna Dolan Characterization of Internally-Quenched Fluorescent Peptide Substrates for the Peptidase Neurolysin. abstract chemistry
12 Chyna Johnson Design and Synthesis of STAT3 Inhibitor abstract chemistry
13 Marceline G. Aengwanama Runx1 Interacts With DeltaNp63alpha to Regulate Target Genes abstract chemistry
14 Dipendra Sharma Chapagain Influence of Boundary Conditions on Metastable Lifetimes for The Ising Model on the Hyperbolic Plane chemistry
15 Kristina Carter, Sara Dean, Valerie Frost, & Alena Gordienko From Anecdote to Assessment: the Robust Beauty of Using Multiple Regression and Path Analysis to Explore Retention, Graduation, and Academic Performance at a Small Liberal Arts College chemistry
16 Stacey Roberts & Brittany Stowers African American Families and their Heritage in Garrard County Kentucky--Phases I and II abstract child and family studies
17 Aaron Meadows Taiji Improves Kinetic Link Coordination abstract other
18 Marissa Brown, Mackenzie Endres, Rohan Isaac, & Tommy Boykin Laser Ablation of Boron Fullerenes abstract physics
19 James Perrugia & Fidel Tewolde Ground State Energies and Isomer Configurations of Nanoclusters abstract physics
20 Christopher B. Yaluma The Identification of Few Layer Graphene and the Growth of Nanoribbons on Silicon Nitride Substrates abstract physics
21 Andrew Miller Structural Analysis of integrin Beta 1. physics
22 Joshua Callahan, Yuta Katsumi, Chido Matara, & Shelby Williams Neurophysiological Indices of Cognitive Style abstract psychology
23 Brian Easterday, Tierah Ellard, Matthew Jenkins, & Jordan Monger Design of a flexible research vehicle for future studies at Berea College abstract technology & industrial arts
24 Sam Hawes The History, the Music and the Construction of the Kentucky Dulcimer technology & industrial arts