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Office Hours:
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Contact:
jay_baltisberger@berea.edu

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2011 Berea College Research Symposium

The Berea Undergraduate Research Symposium (BURS), held each fall the same weekend that the Berea College Trustees visit campus, is an opportunity for the students and faculty to share research work with each other as well as these important campus visitors. This has been organized by the science departments in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The program for Fall 2011 will be held on Friday, October 21st. The 2011 BURS will start in the afternoon with student oral presentations, continue with student poster presentations, and and with a plenary talk by Dr. Doug Stickle. Dr. Stickle is Professor and Director of Chemistry & Point-of-Care Testing (POCT) at Jefferson University Hospitals in Philadelphia. Dr. Stickle's talk is titled, “Clinical Chemistry, and Clinical Applications of Mass Spectrometry”.
We will start at 2:30 PM with two simultaneous oral presentation sessions (15 minutes each) in rooms 101 and 106 of the Science Building. The sessions are grouped by theme as much as possible. The poster session starts at 3:30 and is held in the lobby of the science building with posters from various fields (previous posters from chemistry, biology, physics, psychology, sociology, education, African American Studies, economics, industrial arts, computer science, physical education & health, and mathematics). All students who pursued substantial research projects over the previous year are encouraged to present their research.
Students and faculty interested in attending or participating in the 2018 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

Epitope Mapping of Vimentin in Arthritis-susceptible HLA-DRB1* 0401 and resistant *0402 mice

Kelly Mouapi
Mentor: Veena Taneja & Chella David
Performed at Mayo Clinic
Predisposition to rheumatoid arthritis (RA) has been associated with the presence of human leukocyte antigen (HLA) class II molecules-DR and DQ. Patients with RA produce antibodies to Vimentin and harbor Vimentin-reactive T cells. It has been hypothesized that the response to Vimentin precedes onset of RA, and is associated with presence of HLA-DRB1*0401 gene. To investigate the role of DR4 in susceptibility and resistance to arthritis, mice expressing *0401 and *0402 gene, but lacking endogenous class II molecules, were generated. Transgenic mice were immunized with Vimentin and challenged in vitro with 20mer Vimentin-peptides. Using this approach we confirmed the epitopes present in RA patients and also identified two new epitopes in *0401 and *0401/DQ8 mice. Further, we showed that females generated a higher response to the Vimentin peptides compared to males. Arthritis-resistant *0402 mice generated a response to Vimentin and its peptides although *0402 and *0401 mice clearly responded to different peptides. Interestingly, naïve *0401 and *0402 mice also generated mild response to Vimentin and its peptides. The two new epitopes identified in immunized mice were also responsive in naïve *0401 mice suggesting their role in pathogenesis.


Registration for the 103rd Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2011

Oral Presentations

# Name Host Title Mentor Major
1 Ericka Berge, Bailey King, Michon Martin, Juliana Dolan, & Franceska Mehmeti Berea College Proterometra macrostoma (Trematoda: Azygiidae): Location of the Redia and Emergence Path from the Snail Intermediate Host, Elimia semicarinata (Gastropoda: Pleuorceridae). abstract Ron Rosen biology
2 Imelda Hot Penn State College of Medicine, Hershey PA Blood Plasma Coagulation Induced by Poly(ethylene glycol) Materials abstract Christopher A. Siedlecki chemistry
3 Marceline G. Aengwanama Vanderbilt University Runx1 Interacts with Delta Np63alpha to Regulate Target Genes abstract Christopher E Barton & Jennifer A Pietenpol chemistry
4 Kelly Mouapi Mayo Clinic Epitope Mapping of Vimentin in Arthritis-susceptible HLA-DRB1* 0401 and resistant *0402 mice abstract Veena Taneja & Chella David chemistry
5 Premila Samuel Mayo Clinic The mechanism of action of Prevotella histocola in the immunomodulation of experimental autoimmune encephalomyelitis (EAE). abstract Ashutosh Mangalam chemistry
6 Chido Hambira & Michael Bertucci University of North Carolina at Chapel Hill Combinatorial synthesis of a thiourea library for the aminolysis of N-acyl homoserine lactones abstract Michel Gagné chemistry
7 Lydia Joiner Berea College Berea College Gardeing Project abstract Neil Mecham child and family studies
8 Tommy O. Boykin Berea College Synthesis of Copper-Based Superconductors abstract Amer Lahamer physics
9 Rohan Isaac, Tommy Boykin, Marissa Brown, & Mackenzie Endres Berea College Synthesis and characterization of Half-Metallic Heusler Alloys abstract Amer Lahamer physics
10 Rachel Krebs Berea College The effects of gender and writing assignments on implicit attitudes of gender roles abstract Dave Porter psychology
11 Raven Weaver Berea College Perception of Aging: The Power of Knowledge & Action abstract Dave Porter psychology

Poster Presentations

# Name Host Title Mentor Major
1 Juliana Dolan, Franceska Mehmeti, Ericka Berg, Bailey King, & MIchon Martin Berea College Proterometra macrostoma (Trematoda: Azygiidae): Effect of Serotonin and Melatonin on Redial Movement and Emergence of the Cercaria from the Redia and the Snail, Elimia semicarinata (Gastropoda: Pleuorceridae). abstract Ron Rosen biology
2 Karen Reynolds University of Kentucky Understanding SERF function: Creation and behavioral analysis of dSERF deletion mutants abstract Dr. Raymond & Dr. Harrison biology
3 Katherine Webb Berea College Detection and mapping of invasive plant species and hiking trails at Indian Fort Mountain in Berea, KY. Dr. Hanna biology
4 Cecilia Albers Vanderbilt University The Role of Activated Leukocyte Cell Adhesion Molecule in Triple Negative Breast Cancer abstract Bojana Jovanovic biology
5 Charli Bobbitt Vanderbilt University The Role of Bone Morphogentic Proteins in Mammary Gland Differentiation Phil Owens biology
6 Horton Li Vanderbilt University LKB1 effect on MicroRNA expression in lung adenocarcinoma abstract Jacob M. Kaufman, Joseph M. Amann, & David P. Carbone chemistry
7 Dallas Cook, Russell Hammond, & Horton Lin Berea College Synthesis of Fluorescent Derivatives of Lysine and Glutamic Acid abstract Matthew Saderholm chemistry
8 Trena Payton & Amanuel Tefamichael Berea College Synthesis of Enantioenriched β-Ketoesters via a Quinine-Catalyzed Ketene-Claisen Condensation. abstract Mary Robert Garrett chemistry
9 Chelsey Lloyd & Michelle Bloom Berea College Synthesis of Enantioenriched β-Ketoesters via an Azaferrocene-Catalyzed Ketene-Claisen Condensation abstract Mary Robert Garrett chemistry
10 Amanuel Tesfamichael & Trena Payton Berea College Synthesis of Enantioenriched β-Ketoesters via a Ketene-Claisen Condensation. Mary Robert Garrett chemistry
11 Diego Moya, Elijah Whitaker, Melanie Burt, & Julianna Dolan Berea College Characterization of Internally-Quenched Fluorescent Peptide Substrates for the Peptidase Neurolysin. abstract Matthew Saderholm chemistry
12 Chyna Johnson Miami University Design and Synthesis of STAT3 Inhibitor abstract Hong Wang chemistry
13 Marceline G. Aengwanama Vanderbilt University Runx1 Interacts With DeltaNp63alpha to Regulate Target Genes abstract Christopher E Barton & Jennifer A Pietenpol chemistry
14 Dipendra Sharma Chapagain Marshall University Influence of Boundary Conditions on Metastable Lifetimes for The Ising Model on the Hyperbolic Plane Howard Richards chemistry
15 Kristina Carter, Sara Dean, Valerie Frost, & Alena Gordienko Berea College From Anecdote to Assessment: the Robust Beauty of Using Multiple Regression and Path Analysis to Explore Retention, Graduation, and Academic Performance at a Small Liberal Arts College Dave Porter chemistry
16 Stacey Roberts & Brittany Stowers Berea College African American Families and their Heritage in Garrard County Kentucky--Phases I and II abstract Janice Blythe child and family studies
17 Aaron Meadows Berea College Taiji Improves Kinetic Link Coordination abstract Jeff McClung other
18 Marissa Brown, Mackenzie Endres, Rohan Isaac, & Tommy Boykin Berea College Laser Ablation of Boron Fullerenes abstract Amer Lahamer physics
19 James Perrugia & Fidel Tewolde Berea College Ground State Energies and Isomer Configurations of Nanoclusters abstract Martin Veillette physics
20 Christopher B. Yaluma University of Kentucky The Identification of Few Layer Graphene and the Growth of Nanoribbons on Silicon Nitride Substrates abstract Douglas Strachan physics
21 Andrew Miller Vanderbilt University Structural Analysis of integrin Beta 1. Roy Zent physics
22 Joshua Callahan, Yuta Katsumi, Chido Matara, & Shelby Williams Berea College Neurophysiological Indices of Cognitive Style abstract Rob Smith psychology
23 Brian Easterday, Tierah Ellard, Matthew Jenkins, & Jordan Monger Berea College Design of a flexible research vehicle for future studies at Berea College abstract Mark Mahoney technology & industrial arts
24 Sam Hawes Berea College The History, the Music and the Construction of the Kentucky Dulcimer Alan Mills technology & industrial arts