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Science Building
CPO 2191
859-985-3318

Office Hours:
M–F, 8:00 a.m.–5:00 p.m.

Contact:
jay_baltisberger@berea.edu

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2008 plenary speaker, Dr. Mark Lovell

2008 Berea College Research Symposium

The research symposium held each fall the same weekend that the Berea College Trustees visit campus is an opportunity for the students and faculty to share research work with each other as well as these important campus visitors. This has been organized by the science departments in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The symposium for Fall 2008 was held on Friday, October 17th starting after lunch and concluding with a plenary talk titled “A Search for Novel Biomarkers of Alzheimer’s Disease” by Dr. Mark Lovell who works at the University of Kentucky. Mark is also a Berea College graduate so it was exciting to bring him back to campus to share his work.
Students and faculty interested in attending or participating in the 2019 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

HER2-overexpressing, PIK3CA mutated breast cancer cells rely on HER3 for their survival

Oliver Munyaradzi
Mentor: Anindita Chakrabarty & Carlos Artegag
Performed at Vanderbilt University
The phosphatidylinositol 3-kinase (PI3K) pathway regulates many cellular processes including proliferation, growth, survival and migration. In many breast tumors, hyperactivation of the pathway occurs via two major mutations in E545K (exon 9) and H1047R (exon 20) of the p110α gene (PIK3CA), the catalytic subunit of PI3K. Binding of growth factors to their receptor tyrosine kinase (RTK) serves as a major stimulus for activation of the PI3K pathway. HER2 (Human Epidermal Growth Factor Receptor/EGFR-2), an RTK oncogene amplified in 25% of breast cancers, is a potent inducer of the PI3K pathway. Much of the signaling activity through HER2 occurs via heterodimerization with HER3. Very little is known about the mechanisms underlying the activation of the PI3K pathway by RTKs like HER2 and HER3. The objective of our study was to determine whether breast cancer-associated PIK3CA mutants rely on HER3 for their activation and tumorigenic potential in the same way as wild-type PIK3CA. We performed siRNA-mediated knock-down of HER3 in MCF10A human mammary epithelial cells engineered to over-express HER2 and H1047R PIK3CA mutation and in UACC893 breast cancer cells with endogenous HER2 amplification and H1047R PIK3CA mutation. We compared the survival of the control versus HER3 siRNA-transfected cells by proliferation assay and crystal violet staining. HER3 knock-down had a dramatic effect on survival of breast epithelial or tumor cells co-expressing HER2 and H1047R PIK3CA mutation. These observations suggest that similar to the WT PI3K, the H1047R oncogenic mutant relies on the HER2-associated HER3 signaling in HER2 positive breast cancer cells.


Registration for the 105th Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2008

Oral Internship Presentations

# Name Host Title Mentor Major

Oral Research Presentations

# Name Host Title Mentor Major
1 Dikshya Bastakoty Vanderbilt University p63 defines an epithelial phenotype and represses mesenchymal-specific gene, COL5A1 abstract Christopher E Barton & Jennifer A Pietenpol biology
2 Jessica R. Price Conservation and Research for Endangered Species Behavioral Ecology and Translocation of the Endangered Stephens' Kangaroo rat (Dipodomys stenphensi). abstract Conservation and Research for Endangered Species biology
3 Jessica R. Price Tropical Ecology and Conservation Influence of Elevation, Host Species, and Host Size on the Density of Mistletoe, Phoradendron robustissimum (Viscaceae) in Costa Rica abstract Monteverde, Costa Rica biology
4 Megan Jackson Mayo Clinic Effect of commensal bacterium, Prevotella nanceiensis, on experimental autoimmune encephalomyelitis, an animal model for Multiple Sclerosis abstract C. David biology
5 Miluka Gunaratna Vanderbilt University The loss of stromal TGF-β leads to increased expression of STATIP1 abstract Veronica Placencio, Xiaohong Li, Ali-Reza Sharif-Afshar, Magaly Martinez-Ferr, & Neil Bhowmick biology
6 Anthony Reynolds University of Utah Liquid-liquid phase transition of nanoscaled supercooled silicon SURP chemistry
7 Justin Cornelison, Enchanta Jackson Berea College Restoring the Oliver Street Community School: History and Preservation abstract Dwayne Mack other
8 Ehidiamhen Akhetuamhen, Arlett Franco Berea College Living in Hope in Louisville: An Assessment of the Hope VI Redevelopment Project abstract Michelle Tooley other
9 David Gilmour, William Dean Norris Berea College Laser Ablation of Diamond abstract Amer Lahamer physics
10 Bradley Steele, Brandon Brown Berea College Numerical Simulations of Disorder in Classical Spin Models abstract Martin Veillette physics
11 Jimmy Rop, Ramesh Adhikari, Chase Cole Berea College Variable Star Observations at the Berea College Observatory abstract Tracy Hodge physics

Poster Presentations (Research and Internship)

# Name Host Title Mentor Major
1 Alaina Faust, Alisha Holmberg, Elizabeth Fleming Berea College Proterometra macrostoma (Digenea: Azygiidae): The effect of osmolality on the retraction of the distome body into its cercarial tail abstract Ron Rosen biology
2 Oliver Pogue Berea College Effects of human disturbance on ground beetle diversity abstract Sean Clark biology
3 Patricia Stephens, Yili Gan, Jordan Harrison Berea College The Perception of Phagostimulants Is Context Dependent in Larval Manduca Sexta abstract Marc Rowley biology
4 Tsering Dolma University of Utah Kinetic Imaging of Single Molecule Interaction (KISMI): SNARE Proteins and UNC-18 Interactions abstract Chris Hopkins, Wayne Davis, & Erik Jorgensen biology
5 Kayla G. Kinker University of Kentucky Analysis of the Telomere Position Effect and the Role of RecQ Helicases in the Genomic Integrity of Model Organism Aspergillus Nidulans abstract KBRIN biology
6 Kabindra Kafle, Efua Wilmot Berea College Design and synthesis of Proline Containing Cationic antimicrobial peptides ( PCAMPS) abstract Matthew Saderholm chemistry
7 Donia Arthur Berea College Chelation and N-Heterocyclic Carbene Complexes abstract Anes Kovacevic chemistry
8 Josh Schmeling, Theint Theint Berea College Pyridylidene N-Heterocyclic Carbene Complexes abstract Anes Kovacevic chemistry
9 Etagegn Bekele University of Kentucky SOLUBILITY DETERMINATION OF SILATECAN 7-t-BUTYLDIMETHYLSILYL-10-HYDROXYCAMPTOTHECIN (DB-67) IN VITAMIN-E TPGS IN THE PRESENCE AND ABSENCE OF A SECONDARY EXCIPIENT Pharmaceutical Science, College of Pharmacy chemistry
10 Oliver Munyaradzi Vanderbilt University HER2-overexpressing, PIK3CA mutated breast cancer cells rely on HER3 for their survival abstract Anindita Chakrabarty & Carlos Artegag chemistry
11 Andrea Paezold Berea College Dancing: Dance and Choreography Intelligent Nondeterministic Generator Mario Nakazawa computer science
12 Jessica Carnes, Amy Jones Berea College Scientific Inquiry: Factors that influence evolution of scientific skills and disposition abstract Jon C. Saderholm other
13 Shannon Baldon, Amber Stanton Berea College In Search of Us: Black Women Identifying 'Right' Representation in Contemporary Films Kennaria C. Brown other
14 Ashley Crockett Berea College Self-Selected Walking Pace as a Predictor of Maximal Oxygen Consumption abstract Jeff McClung physical education & health
15 Matthew Bailey University of Wisconsin-Madison, Department of Astrophysics Investigating Blue Straggler Production without Cluster Dynamics: A Binary-Evolution-Only Approach abstract Robert Mathieu & Aaron Geller physics
16 Danielle Pelenkahu Berea College Sometimes you can’t win for losing; The effect of stereotype threat on Sudoku performance abstract Dave Porter psychology
17 Samantha Buchanan Berea College The Effects of Physical Appearance and Subjective Description on Rated Likability abstract Dave Porter psychology
18 Lacey Owens Berea College The Effects of Gender and Condition on Fifth Graders' Block Stacking Performance abstract Dave Porter psychology
19 John Damron Berea College To Tell the Truth: The Effects of Viewer and Presenter Personal Political Preferences on Perceptions of Sincerity abstract Dave Porter psychology
20 Brian Owens Berea College Robbers Cave Revisted: The Effects of Race and Instructions on Implicit and Explicit measures of Racial Prejudice abstract Dave Porter psychology
21 Julia Price Berea College The Effects of Object Familiarity and time on Incidental Recall abstract Dave Porter psychology
22 Kaleigh McCoy, Megan Rodgers, Bozhidar Bashkov, Angela Sutton Berea College Predicting Academic Success in the Third Semester abstract Dave Porter psychology
23 Debra Bulluck, Kim-Dung Nguyen Berea College Kentucky African American Encyclopedia: Black Life and Culture in the Commonwealth abstract Jackie Burnside, Andrew Baskin sociology
24 Christopher Dueker, George Shea, Noah McGraw Berea College Development of Ultralight Personal Electric Vehicles abstract Brad Christensen technology & industrial arts