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2007 plenary speaker, Dr. Sheila David research group

2007 Berea College Research Symposium

The research symposium held each fall the same weekend that the Berea College Trustees visit campus is an opportunity for the students and faculty to share research work with each other as well as these important campus visitors. This has been organized by the science departments in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The symposium for Fall 2007 was held on Friday, October 19th starting after lunch and concluding with a plenary talk titled "Dare to Repair: from Cancer to Chemistry," by Shiela David who is a biochemist doing DNA repair work at the University of California, Davis. It is a pleasure to have Shiela here for the plenary talk because she and her father (who is a Berea College trustee) have been so generous to Berea over the years with support. The complete listing of seminars and posters is given below.
Students and faculty interested in attending or participating in the 2018 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

Abrogation of TGF-B signaling in mammary carcinomas recruits myeloid immune suppressor cells through CXCL5/CXCR2 chemokine axis

Megan Jackson
Mentor: Hal Moses
Performed at Vanderbilt University
TGF-β is a very important tumor suppressor. Inactivation or alteration of TGF-β signaling is common in human cancers. We have previously observed that deletion of Tgfbr2 gene results in increased breast tumor progression and metastasis. However, the mechanism behind this observation is unclear. Myeloid immune suppressor cells, or MISCs, are host cells that are known to be immune suppressive and tumor promoting. As CXCL5 production is increased in breast adenocarcinomas with Tgfbr2 deletion, we hypothesize that CXCL5 interacts with its specific receptor CXCR2 and results in MISC recruitment into the tumor microenvironment, thus promoting tumor progression and metastasis. Studies were performed to elucidate the recruitment of MISCs in vivo MMTV PyVmT mouse model with specifically the deletion of TGF-B signaling in mammary adenocarcinomas. Mice bearing MMTV PyVmT Tgfbr2 knock out tumor or floxed control tumor were treated with a CXCR2 receptor antagonist SB-265610 at 2 mg/kg/ day by I.P. injection. This treatment with SB-265610 significantly reduced the recruitment of MISCs to Tgfbr2 null breast tumors but not the control tumors. From this study it can be concluded that therapeutic intervention to interrupt the CXCL5/CXCR2 chemokine axis may decrease the recruitment of MISCs to the tumor microenvironment with decreased TGFB signaling thus inhibit breast cancer progression.


Registration for the 103rd Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2007

Oral Presentations

# Name Host Title Mentor Major
1 Richard Cooks, Jessica Price Argonne National Laboratory Design and Development of Palladium-Iron Bimetallic Electrocatalysts for Polymer Electrolyte Fuel Cells abstract Mark Cunningham biology
2 Enrique Garcia Vanderbilt University Defining the mechanism of EP4-mediated metastasis abstract David Carbone biology
3 Elizabeth Fleming Miami University Source and Photodegredation of Dissolved Organic Matter as Factors of Fluoranthene Phototoxicity to Daphina magna abstract Jim Oris & Craig Williamson biology
4 Amanda Hensley Berea College Inositol Increases Feeding on Deterrent Mixtures in Larval Manduca sexta abstract Marc Rowley biology
5 Rebecca Linville Berea College Identifying Genes that Interact with CRMP During Neurogenesis in Drosophila melanogaster abstract John Rawls biology
6 Joshua Sparks Mayo Clinic Of Mice and Men - Do Arthritis Resistant Mice Provide Clues to Protection from Rheumatoid Arthritis? abstract Veena Taneja biology
7 Rachel Saunders Mayo Clinic Role of MHC Class II on Mouse Regulatory T Cells abstract Chella David biology
8 Megan Jackson Vanderbilt University Abrogation of TGF-B signaling in mammary carcinomas recruits myeloid immune suppressor cells through CXCL5/CXCR2 chemokine axis abstract Hal Moses biology
9 Gloria Fritz University of Louisville Psychophysiological Study of Response Conflict and Error Processing Deficits in Patients with Posttraumatic Stress Disorder abstract Tato Sokhadze biology
10 Din Obadele Mandley Berea College Chemical and NMR Analysis of Soil Phosphorus Affected by Waste Overflow abstract Paul Smithson chemistry
11 Anthony Reynolds SUNY Stony Brook The Synthesis of Aluminum Magnesium Layered Double Hydroxides (LDH) and Characterization of Phosphate Ion Exchange Experiments abstract Clare Grey, Center for Environmental Molecular Science chemistry
12 Diana Gudkova Georgia State University CLASSICAL Be STARS Center for High Resolution Astronomy (CHARA) mathematics

Poster Presentations

# Name Host Title Mentor Major
1 Clarissa Harris University of Kentucky Dopamine Transporter Expression in a "Two Hit" Rat Model of Parkinsonian Syndrome abstract Jim Pauly biology
2 Kate Johnson Berea College Inositol Increases Feeding on Deterrent Mixtures in Larval Manduca sexta abstract Marc Rowley biology
3 Jacob Gunnell, Jessica Lanfair, Jenna Ott Berea College Metagenomic Characterization of Mirobial Communities of the Berea College Living Machine abstract Dawn Anderson biology
4 Brittni Ross, Christopher Barton, Kimberly Johnson, & Deborah Mays Vanderbilt University Identification of Genes Regulated by p63 in Human Epithelia abstract Jennifer Pietenpol biology
5 Meiping Sun University of Kentucky Nick-directed Loop Mismatch DNA Excision in Human Cells abstract Guo-Min Li biology
6 Dikshya Bastakoty, Aaron Fidler, Miluka Gunaratna Berea College Proterometra macrostoma (Trematoda: Azygiidae): Further Studies on the Strain Question at North Elkhorn Creek, Scott County, KY abstract Ron Rosen biology
7 Tsering Dolma, Robert Twiggs, Brea Viragh Berea College Factors Affecting the Emergence, Infectivity and Subsequent Development of the Proterometra macrostoma (Trematoda: Azygiidae) Cercaria abstract Ron Rosen biology
8 Spencer Gravitt, Oliver Pogue Berea College Population Dynamics of Varroa Mite (Acari: Varroidae) on Different Honey Bee (Hymenoptera: Apidae) Stocks abstract Sean Clark biology
9 Laxman Gurung University of Southern California Synthesis of Vinyl Fluorides from Alkyl Halides and Alcohols abstract G.K. Surya Prakash chemistry
10 Thabiso Musapelo Berea College Homonuclear Decoupling and INADEQUATE NMR abstract Jay Baltisberger chemistry
11 Marek Counts, Kayla Meadows Berea College Normal and Abnormal N-Heterocyclic Carbene Complexes abstract Anes Kovacevic chemistry
12 Kaleigh McCoy Berea College Where Have All the Students Gone? Factors Influencing the Retention and Academic Success of Students Who Entered Berea College in the Fall of 2006 abstract Dave Porter other
13 Genesis Song University of Kentucky Kinetics of the Degradation of Aspirin Tonglei Li other
14 Kannatassen Appavoo, Robert Shelby, Simone Raoux, & Delia Milliron Berea College & IBM Almaden Research Center Effect of doping novel thin film Sb2Te phase-change material on its optical and switching time property abstract Amer Lahamer physics
15 David Gilmour, Brad Steele Berea College Producing Fullerenes Using Laser Ablation abstract Amer Lahamer physics
16 Shiblee Ratan Barua University of Arkansas Prospects for LISA to detect the Christodoulou memory of gravitational waves abstract Daniel Kennefick physics
17 Mohammed Humed Yusuf & Bryan Gover Berea College Photometry of Summer Variable Stars abstract Tracy Hodge physics
18 James Rittmann Berea College Exercise and Memory: the Immediate Effects of Exercise on Memory Dave Porter psychology
19 Charla Ruble Berea College The Effects of Student's Alcohol Use and Death Self-Reflection on their Perception of Risk Taking Behavior Dave Porter psychology
20 Tian Wei Berea College The effect of gender, condition and comparative ignorance on investment and confidence Dave Porter psychology