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Science Building
CPO 2191
859-985-3318

Office Hours:
M–F, 8:00 a.m.–5:00 p.m.

Contact:
jay_baltisberger@berea.edu

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2007 plenary speaker, Dr. Sheila David research group

2007 Berea College Research Symposium

The research symposium held each fall the same weekend that the Berea College Trustees visit campus is an opportunity for the students and faculty to share research work with each other as well as these important campus visitors. This has been organized by the science departments in the past but participation is open to all members of the college community. In recent years we have structured the symposium with both talks and poster presentations as well as a plenary session.
The symposium for Fall 2007 was held on Friday, October 19th starting after lunch and concluding with a plenary talk titled "Dare to Repair: from Cancer to Chemistry," by Shiela David who is a biochemist doing DNA repair work at the University of California, Davis. It is a pleasure to have Shiela here for the plenary talk because she and her father (who is a Berea College trustee) have been so generous to Berea over the years with support. The complete listing of seminars and posters is given below.
Students and faculty interested in attending or participating in the 2017 BURS should either contact Jay Baltisberger or Anes Kovacevic of the chemistry program. Alternatively a student may elect to register online via the link on the Chemistry department web server.

Defining the mechanism of EP4-mediated metastasis

Enrique Garcia
Mentor: David Carbone
Performed at Vanderbilt University
Metastasis, the spread of a primary tumor to distant sites, is responsible for much of the mortality associated with cancer. Increased levels of the arachidonic acid metabolite, PGE2, have been correlated with metastasis and poor outcome for cancer patients. PGE2 operates through the E Prostaglandin Receptors (EP1-4) that are G-protein-coupled receptors (GPCRs), which mediate intracellular signaling. Literature supports the involvement of EP4, one of the four subtypes, in cancer metastasis. Inhibition or knockdown of this receptor in cancer cells greatly reduces the number of metastases in several mouse models. However, the mechanism of EP4-mediated metastasis has yet to be elucidated. We created a series of EP4/EP2 chimeric proteins designed to test particular EP4 regions that may be involved in the metastatic process. We examined the ability of these chimeric proteins to phosphorylate downstream proteins implicated in metastasis such as AKT/PKB and ERK. We are also looking at the platelet-cancer cell interaction in metastasis. Platelets tend to aggregate around a cancer cell shielding it from the immune system and aiding in the cancer cell’s extravasion into a new site. We would like to determine if EP4 is involved in the interaction tumor cells with platelets. By using EP4 inhibitors and cancer cells with EP4 protein knocked down with a shRNA construct, it is our intention to show that EP4 contributes to metastasis by regulating the proteins necessary to allow cancer cell interactions with platelets. Defining these mechanisms may lead to better cancer treatments that halt metastasis, improving patient outcomes.


Registration for the 103rd Kentucky Academy of Sciences Meeting should follow this link KAS Registration

The following students have registered to do presentations for 2007

Oral Presentations

# Name Title Major
1 Richard Cooks, Jessica Price Design and Development of Palladium-Iron Bimetallic Electrocatalysts for Polymer Electrolyte Fuel Cells abstract biology
2 Enrique Garcia Defining the mechanism of EP4-mediated metastasis abstract biology
3 Elizabeth Fleming Source and Photodegredation of Dissolved Organic Matter as Factors of Fluoranthene Phototoxicity to Daphina magna abstract biology
4 Amanda Hensley Inositol Increases Feeding on Deterrent Mixtures in Larval Manduca sexta abstract biology
5 Rebecca Linville Identifying Genes that Interact with CRMP During Neurogenesis in Drosophila melanogaster abstract biology
6 Joshua Sparks Of Mice and Men - Do Arthritis Resistant Mice Provide Clues to Protection from Rheumatoid Arthritis? abstract biology
7 Rachel Saunders Role of MHC Class II on Mouse Regulatory T Cells abstract biology
8 Megan Jackson Abrogation of TGF-B signaling in mammary carcinomas recruits myeloid immune suppressor cells through CXCL5/CXCR2 chemokine axis abstract biology
9 Gloria Fritz Psychophysiological Study of Response Conflict and Error Processing Deficits in Patients with Posttraumatic Stress Disorder abstract biology
10 Din Obadele Mandley Chemical and NMR Analysis of Soil Phosphorus Affected by Waste Overflow abstract chemistry
11 Anthony Reynolds The Synthesis of Aluminum Magnesium Layered Double Hydroxides (LDH) and Characterization of Phosphate Ion Exchange Experiments abstract chemistry
12 Diana Gudkova CLASSICAL Be STARS mathematics

Poster Presentations

# Name Title Major
1 Clarissa Harris Dopamine Transporter Expression in a "Two Hit" Rat Model of Parkinsonian Syndrome abstract biology
2 Kate Johnson Inositol Increases Feeding on Deterrent Mixtures in Larval Manduca sexta abstract biology
3 Jacob Gunnell, Jessica Lanfair, Jenna Ott Metagenomic Characterization of Mirobial Communities of the Berea College Living Machine abstract biology
4 Brittni Ross, Christopher Barton, Kimberly Johnson, & Deborah Mays Identification of Genes Regulated by p63 in Human Epithelia abstract biology
5 Meiping Sun Nick-directed Loop Mismatch DNA Excision in Human Cells abstract biology
6 Dikshya Bastakoty, Aaron Fidler, Miluka Gunaratna Proterometra macrostoma (Trematoda: Azygiidae): Further Studies on the Strain Question at North Elkhorn Creek, Scott County, KY abstract biology
7 Tsering Dolma, Robert Twiggs, Brea Viragh Factors Affecting the Emergence, Infectivity and Subsequent Development of the Proterometra macrostoma (Trematoda: Azygiidae) Cercaria abstract biology
8 Spencer Gravitt, Oliver Pogue Population Dynamics of Varroa Mite (Acari: Varroidae) on Different Honey Bee (Hymenoptera: Apidae) Stocks abstract biology
9 Laxman Gurung Synthesis of Vinyl Fluorides from Alkyl Halides and Alcohols abstract chemistry
10 Thabiso Musapelo Homonuclear Decoupling and INADEQUATE NMR abstract chemistry
11 Marek Counts, Kayla Meadows Normal and Abnormal N-Heterocyclic Carbene Complexes abstract chemistry
12 Kaleigh McCoy Where Have All the Students Gone? Factors Influencing the Retention and Academic Success of Students Who Entered Berea College in the Fall of 2006 abstract other
13 Genesis Song Kinetics of the Degradation of Aspirin other
14 Kannatassen Appavoo, Robert Shelby, Simone Raoux, & Delia Milliron Effect of doping novel thin film Sb2Te phase-change material on its optical and switching time property abstract physics
15 David Gilmour, Brad Steele Producing Fullerenes Using Laser Ablation abstract physics
16 Shiblee Ratan Barua Prospects for LISA to detect the Christodoulou memory of gravitational waves abstract physics
17 Mohammed Humed Yusuf & Bryan Gover Photometry of Summer Variable Stars abstract physics
18 James Rittmann Exercise and Memory: the Immediate Effects of Exercise on Memory psychology
19 Charla Ruble The Effects of Student's Alcohol Use and Death Self-Reflection on their Perception of Risk Taking Behavior psychology
20 Tian Wei The effect of gender, condition and comparative ignorance on investment and confidence psychology