Deformylflustrabromine B is a recently discovered (2004) marine natural product from the benthic North Sea bryozoan Flustra foliacea. Deformylflustrabromine B was found to bind and inhibit the alpha 7 subtype of the Nicotinic receptor in the micromolar range. In order to increase binding to the alpha 7 receptor, we used the docking program, ICH MOLSOFT to design various analogs of Deformylflustrabromine B. We present here the synthesis of one analog, Analog 3. This and other analogs will be used in assays to test for increased biological activity compared to the lead compound.

---

modify this info
Return to abstract page

---

Any students who may have been left off this list feel free to email Dr. Baltisberger at jay_baltisberger@berea.edu and your address and other information will be added to this home page.